Publications
1. NR Gandasi, P Rorsman (2024). An unclear role for the GLP-1 metabolite GLP-1 (9–36) in human islet physiology. Reply to Matveyenko A, Vella A. Diabetologia, 1-2 2024
2. S Paul, A Pallavi, NR Gandasi# (2024) Exploring the potential of pheophorbide A, a chlorophyll-derived compound in modulating GLUT for maintaining glucose homeostasis. Frontiers in Endocrinology 15, 1330058 2024. #corresponding author
3. M Singh and NR Gandasi# (2024) Intricate interplay between endocrine and exocrine pancreas. iScienceNotes – accepted - #corresponding author
4. AA Makam, A Dubey, S Maharana, NR Gandasi# (2023) Algorithm for automatic detection of insulin granule exocytosis in human pancreatic β-cells. bioRxiv, 2023.11. 14.566999. #corresponding author
5. NR Gandasi, R Gao, L Kothegala, A Pearce, C Santos, S Acreman, ...P Rorsman (2023) GLP-1 metabolite GLP-1 (9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion. Diabetologia, 1-19
6. P Veerabhadraswamy, P Belekar, L Kothegala, NR Gandasi# (2023), Localization and function of multivesicular-bodies that release exosomes in islet cells: dysregulation during type-2 diabetes. bioRxiv, 2023.04. 13.536686. #corresponding author
7. NR Gandasi#, A Rangarajan, H Rao, M Singh, L Kothegala (2023), Pancreatic Islet Biobanking Facilities in India: The Need of the Hour to Deal with Diabetes?. Journal of the Indian Institute of Science, 1-5. #corresponding author
8. Kothegala L, Miranda C, Singh M, Krieger J-P, NR Gandasi# (2023), Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes. Int. J. Mol. Sci. 2023, 24(4), 3449. #corresponding author
In the News
9. Global loss of cellular m6A RNA methylation following infection with different SARS-CoV-2 variants (2023), R Vaid, A Mendez, K Thombare, RB Panadero, R Robinot, BF Fonseca, NR Gandasi, J Ringlander, MH Baig, J-J Dong, JY Cho, B Reinius, LA Chakrabarti, K Nystrom, T Mondal. Genome Res. gr.276407.121.
In the News
10. AA Makam, A Biswas, L Kothegala, NR Gandasi# (2022), Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?, Biomedicines Oct 25;10(11):2695. #corresponding author.
11. NR Gandasi#, V Arapi, P Belekar, M Mickael, L Granlund, L Kothegala, R Fredriksson, S Bagchi (2021), Glutamine uptake via SNAT6 and Caveolin regulates glutamine-glutamate, Intl J Mol Sci Jan 25;22(3):1167. #corresponding author.
12. A Hatamie, L Ren, H Dou, NR Gandasi, P Rorsman, AG Ewing (2020). Nanoscale amperometry reveals only a fraction of vesicular serotonin content is released during exocytosis from beta cells, Angew Chem 10.1002/anie.202015902.
13. M Omar-Hmeadi, PE Lund, NR Gandasi, A Tengholm, S Barg (2020). Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes. Nature Communications 11:1896.
In the News
14. V Petrenko, NR Gandasi, D Sage, A Tengholm, S Barg, C Dibner (2020). In pancreatic islets from type 2 diabetes patients the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis. PNAS 117 (5) 2484-2495.
In the News
15. P Nguyen, NR Gandasi, B Xie, S Sugahara, Y Xu, and O Idevall-Hagren (2019). The PI(4)P phosphatase Sac2 controls insulin granule docking and release. Journal of Cell biology 218;11.
In the News
16. Guček A, NR Gandasi, Omar-Hmeadi M, Bakke M, Døskeland SO, Tengholm A, Barg S. (2019) Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis. Elife 20;8. pii: e41711.
17. P Yin, NR Gandasi, S Arora, M Omar-Hmeadi, J Saras, S Barg (2018). Syntaxin clusters at secretory granules in its closed munc18-bound conformation. Molecular biology of the Cell. 1;29(22):2700-2708.
18. M Omar-Hmeadi, NR Gandasi, S Barg (2018). PI(4,5)P2 is not required for secretory granule docking and syntaxin clustering. Traffic 19(6):436-445.
19. SV Korol, Z Jin, Y Jin, AK Bhandage, A Tengholm, NR Gandasi, S Barg, D Espes, PO Carlsson, D Laver, B Birnir (2018) Functional characterization of native, high-affinity GABAA receptors in human pancreatic β cells. eBioMedecine. 30:273-282.
In the News
20. NR Gandasi, P Yin, M Omar-Hmeadi, EO Laakso, P Vikman, S Barg (2018). Glucose dependent granule docking limits insulin secretion and is decreased in human type-2 diabetes. Cell Metabolism 27(2).
In the News
21. VA Salunkhe, JK Ofori, NR Gandasi, SA Salö, S Hansson, ME Andersson, A Wendt, S Barg, JLS Esguerra, L Eliasson (2017). MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles. Physiology Reports 5(21).
22. NR Gandasi#, I Alenkvist#, S Barg, A Tengholm (2017) Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis. Diabetes 66(10):2610-2622. # equal contribution.
In the News
23. NR Gandasi, P Yin, M Riz, G Cortese, M Chibalina, P Rorsman, A Sherman, MG Pedersen and S Barg (2017). Ca2+ channel clustering with insulincontaining granules is disturbed in type 2 diabetes. Journal of Clinical Investigation. 127(6):2353-2364.
In the News
24. Cortese G, NR Gandasi, Barg S, Pedersen MG (2016) Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic β-cells. PLoS ONE 11(12): e0167282.
25. NR Gandasi, K Vestö, M Helou, P Yin, J Saras and S Barg (2015). Survey of red fluorescence proteins as markers for secretory granule exocytosis. PLoS ONE 10(6): e0127801.
26. U Krus, BC King, V Nagaraj, NR Gandasi, J Sjölander, P Buda, E Garcia-Vaz, E Ottosson-Laakso, P Storm, MF Gomez, M Fex, P Vikman, E Zhang, S Barg, AM Blom, and E Renström (2014). The complement inhibitor CD59 plays a fundamental role in insulin secretion by controlling recycling of exocytotic fusion proteins. Cell Metabolism, 19:883-90.
27. NR Gandasi and S Barg (2014). Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site. Nature Communications, 5:3914.
In the News
2. S Paul, A Pallavi, NR Gandasi# (2024) Exploring the potential of pheophorbide A, a chlorophyll-derived compound in modulating GLUT for maintaining glucose homeostasis. Frontiers in Endocrinology 15, 1330058 2024. #corresponding author
3. M Singh and NR Gandasi# (2024) Intricate interplay between endocrine and exocrine pancreas. iScienceNotes – accepted - #corresponding author
4. AA Makam, A Dubey, S Maharana, NR Gandasi# (2023) Algorithm for automatic detection of insulin granule exocytosis in human pancreatic β-cells. bioRxiv, 2023.11. 14.566999. #corresponding author
5. NR Gandasi, R Gao, L Kothegala, A Pearce, C Santos, S Acreman, ...P Rorsman (2023) GLP-1 metabolite GLP-1 (9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion. Diabetologia, 1-19
6. P Veerabhadraswamy, P Belekar, L Kothegala, NR Gandasi# (2023), Localization and function of multivesicular-bodies that release exosomes in islet cells: dysregulation during type-2 diabetes. bioRxiv, 2023.04. 13.536686. #corresponding author
7. NR Gandasi#, A Rangarajan, H Rao, M Singh, L Kothegala (2023), Pancreatic Islet Biobanking Facilities in India: The Need of the Hour to Deal with Diabetes?. Journal of the Indian Institute of Science, 1-5. #corresponding author
8. Kothegala L, Miranda C, Singh M, Krieger J-P, NR Gandasi# (2023), Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes. Int. J. Mol. Sci. 2023, 24(4), 3449. #corresponding author
In the News
9. Global loss of cellular m6A RNA methylation following infection with different SARS-CoV-2 variants (2023), R Vaid, A Mendez, K Thombare, RB Panadero, R Robinot, BF Fonseca, NR Gandasi, J Ringlander, MH Baig, J-J Dong, JY Cho, B Reinius, LA Chakrabarti, K Nystrom, T Mondal. Genome Res. gr.276407.121.
In the News
10. AA Makam, A Biswas, L Kothegala, NR Gandasi# (2022), Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?, Biomedicines Oct 25;10(11):2695. #corresponding author.
11. NR Gandasi#, V Arapi, P Belekar, M Mickael, L Granlund, L Kothegala, R Fredriksson, S Bagchi (2021), Glutamine uptake via SNAT6 and Caveolin regulates glutamine-glutamate, Intl J Mol Sci Jan 25;22(3):1167. #corresponding author.
12. A Hatamie, L Ren, H Dou, NR Gandasi, P Rorsman, AG Ewing (2020). Nanoscale amperometry reveals only a fraction of vesicular serotonin content is released during exocytosis from beta cells, Angew Chem 10.1002/anie.202015902.
13. M Omar-Hmeadi, PE Lund, NR Gandasi, A Tengholm, S Barg (2020). Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes. Nature Communications 11:1896.
In the News
14. V Petrenko, NR Gandasi, D Sage, A Tengholm, S Barg, C Dibner (2020). In pancreatic islets from type 2 diabetes patients the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis. PNAS 117 (5) 2484-2495.
In the News
15. P Nguyen, NR Gandasi, B Xie, S Sugahara, Y Xu, and O Idevall-Hagren (2019). The PI(4)P phosphatase Sac2 controls insulin granule docking and release. Journal of Cell biology 218;11.
In the News
16. Guček A, NR Gandasi, Omar-Hmeadi M, Bakke M, Døskeland SO, Tengholm A, Barg S. (2019) Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis. Elife 20;8. pii: e41711.
17. P Yin, NR Gandasi, S Arora, M Omar-Hmeadi, J Saras, S Barg (2018). Syntaxin clusters at secretory granules in its closed munc18-bound conformation. Molecular biology of the Cell. 1;29(22):2700-2708.
18. M Omar-Hmeadi, NR Gandasi, S Barg (2018). PI(4,5)P2 is not required for secretory granule docking and syntaxin clustering. Traffic 19(6):436-445.
19. SV Korol, Z Jin, Y Jin, AK Bhandage, A Tengholm, NR Gandasi, S Barg, D Espes, PO Carlsson, D Laver, B Birnir (2018) Functional characterization of native, high-affinity GABAA receptors in human pancreatic β cells. eBioMedecine. 30:273-282.
In the News
20. NR Gandasi, P Yin, M Omar-Hmeadi, EO Laakso, P Vikman, S Barg (2018). Glucose dependent granule docking limits insulin secretion and is decreased in human type-2 diabetes. Cell Metabolism 27(2).
In the News
21. VA Salunkhe, JK Ofori, NR Gandasi, SA Salö, S Hansson, ME Andersson, A Wendt, S Barg, JLS Esguerra, L Eliasson (2017). MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles. Physiology Reports 5(21).
22. NR Gandasi#, I Alenkvist#, S Barg, A Tengholm (2017) Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis. Diabetes 66(10):2610-2622. # equal contribution.
In the News
23. NR Gandasi, P Yin, M Riz, G Cortese, M Chibalina, P Rorsman, A Sherman, MG Pedersen and S Barg (2017). Ca2+ channel clustering with insulincontaining granules is disturbed in type 2 diabetes. Journal of Clinical Investigation. 127(6):2353-2364.
In the News
24. Cortese G, NR Gandasi, Barg S, Pedersen MG (2016) Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic β-cells. PLoS ONE 11(12): e0167282.
25. NR Gandasi, K Vestö, M Helou, P Yin, J Saras and S Barg (2015). Survey of red fluorescence proteins as markers for secretory granule exocytosis. PLoS ONE 10(6): e0127801.
26. U Krus, BC King, V Nagaraj, NR Gandasi, J Sjölander, P Buda, E Garcia-Vaz, E Ottosson-Laakso, P Storm, MF Gomez, M Fex, P Vikman, E Zhang, S Barg, AM Blom, and E Renström (2014). The complement inhibitor CD59 plays a fundamental role in insulin secretion by controlling recycling of exocytotic fusion proteins. Cell Metabolism, 19:883-90.
27. NR Gandasi and S Barg (2014). Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site. Nature Communications, 5:3914.
In the News
Book Chapter - NR Gandasi#, V Arapi, P Belekar, M Mickael, L Granlund, L Kothegala, R Fredriksson, S Bagchi (2021), Glutamine-Glutamate Cycle in Neuronal Cells, Prime Archives in Molecular Sciences: 2nd Edition.
#corresponding author
#corresponding author